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<section style="box-sizing: border-box;font-style: normal;font-weight: 400;text-align: justify;font-size: 16px;"><section style="text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><img data-ratio="1.4148148" data-w="1080" src="http://mmbiz.qpic.cn/mmbiz_jpg/mee9Bdh9Tia9wPia9GuxWcbb7vh3vsEdCmkRUibXiacBBNgtjJFt54IkseDRV2fX2ibo2mcicvaqguKA7yTJicEBBKMHQ/640?wx_fmt=jpeg" style="vertical-align: middle;max-width: 100%;box-sizing: border-box;" data-type="jpeg"  /></section></section><section style="text-align: left;margin: 0px 0% -8px;transform: translate3d(10px, 0px, 0px);-webkit-transform: translate3d(10px, 0px, 0px);-moz-transform: translate3d(10px, 0px, 0px);-o-transform: translate3d(10px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 40%;height: 30px;vertical-align: top;overflow-y: auto;box-sizing: border-box;-webkit-overflow-scrolling: touch;"><section style="overflow-x: hidden;box-sizing: border-box;"><section style="margin: 0px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="background-color: rgba(160, 160, 160, 0.62);height: 4px;box-sizing: border-box;line-height: 0;"><br  /></section></section><section style="margin: 0px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="background-color: rgba(160, 160, 160, 0.62);height: 4px;box-sizing: border-box;line-height: 0;"><br  /></section></section></section></section><section style="box-sizing: border-box;margin-top: -30px;height: 30px;"><section style="height: 100%;box-sizing: border-box;"><svg width="40%" height="100%" xmlns="http://www.w3.org/2000/svg" style="box-sizing: border-box transform: rotateZ(0deg);-webkit-transform: rotateZ(0deg);-moz-transform: rotateZ(0deg);-o-transform: rotateZ(0deg);-webkit-transform: rotateZ(0deg);-moz-transform: rotateZ(0deg);-o-transform: rotateZ(0deg);" opacity="0"><svg xmlns="http://www.w3.org/2000/svg" width="100%" height="100%" style="box-sizing: border-box;" x="-0.638998%"><svg width="100%" height="100%" style="box-sizing: border-box;"><rect width="100%" height="100%" style="box-sizing: border-box;opacity: 1;fill: rgb(254, 254, 254);" x="0%"></rect></svg><svg style="width: 100%;height: 100%;box-sizing: border-box;" xmlns="http://www.w3.org/2000/svg"><text x="50%" y="50%" fill="#000000" style="stroke: rgb(0, 0, 0);stroke-width: 1;font-size: 32px;text-anchor: middle;box-sizing: border-box;"> </text></svg><animate attributename="x" style="box-sizing: border-box;" fill="freeze" dur="4" repeatcount="indefinite" begin="0s" keytimes="0;0.5;1" values="100%;0%;-100%"></animate></svg><animate attributename="opacity" style="box-sizing: border-box;" fill="freeze" begin="0s" dur="0.01" from="0" to="1"></animate></svg></section></section></section><section style="text-align: center;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;vertical-align: top;width: 32%;height: auto;box-sizing: border-box;"><section style="margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 95%;height: auto;box-sizing: border-box;"><img data-ratio="2.0088235" data-w="340" src="http://mmbiz.qpic.cn/mmbiz_jpg/mee9Bdh9Tia9wPia9GuxWcbb7vh3vsEdCmolEskWBicrQPicPvrXjdMrrf4UiamoZozibjb5pOGWAGD8IKtMmS8PVPjg/640?wx_fmt=jpeg" style="vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;" width="100%" data-type="jpeg"  /></section></section></section><section style="display: inline-block;vertical-align: top;width: 32%;height: auto;box-sizing: border-box;"><section style="margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 95%;height: auto;box-sizing: border-box;"><img data-ratio="1.9912536" data-w="343" src="http://mmbiz.qpic.cn/mmbiz_jpg/mee9Bdh9Tia9wPia9GuxWcbb7vh3vsEdCmUQTLu2QtyAEww1fdSozg43j0GnCXvFiaM9NHdWSOlS0MZlXO8YpEIwQ/640?wx_fmt=jpeg" style="vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;" width="100%" data-type="jpeg"  /></section></section></section><section style="display: inline-block;vertical-align: top;width: 32%;align-self: flex-start;height: auto;box-sizing: border-box;"><section style="margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 95%;height: auto;box-sizing: border-box;"><img data-ratio="1.9912536" data-w="343" src="http://mmbiz.qpic.cn/mmbiz_jpg/mee9Bdh9Tia9wPia9GuxWcbb7vh3vsEdCmB5LupaYp7wuvML6awBjgdBUBJibzRLHTGtswgwdcDTbdKnoTZJP2q4Q/640?wx_fmt=jpeg" style="vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;" width="100%" data-type="jpeg"  /></section></section></section></section><section style="margin: 10px 0% -5px;box-sizing: border-box;" powered-by="gulangu"><section style="text-align: right;font-size: 14px;color: rgb(160, 160, 160);line-height: 2;letter-spacing: 3px;padding: 0px 20px;box-sizing: border-box;"><p style="margin: 0px;padding: 0px;box-sizing: border-box;">抗击冠状病毒肺炎特刊</p><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 12px;color: rgb(149, 218, 243);box-sizing: border-box;"></span></p><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 12px;box-sizing: border-box;">无以忧国 | 唯以读书</span></p></section></section><section style="text-align: right;margin: 0px 0%;transform: translate3d(-10px, 0px, 0px);-webkit-transform: translate3d(-10px, 0px, 0px);-moz-transform: translate3d(-10px, 0px, 0px);-o-transform: translate3d(-10px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 40%;height: 30px;vertical-align: top;overflow-y: auto;box-sizing: border-box;-webkit-overflow-scrolling: touch;"><section style="overflow-x: hidden;box-sizing: border-box;"><section style="margin: 22px 0% 0px;box-sizing: border-box;" powered-by="gulangu"><section style="background-color: rgba(160, 160, 160, 0.62);height: 4px;box-sizing: border-box;line-height: 0;"><br  /></section></section><section style="margin: 0px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="background-color: rgba(160, 160, 160, 0.62);height: 4px;box-sizing: border-box;line-height: 0;"><br  /></section></section></section></section><section style="box-sizing: border-box;margin-top: -30px;height: 30px;"><section style="height: 100%;box-sizing: border-box;"><svg width="40%" height="100%" xmlns="http://www.w3.org/2000/svg" style="box-sizing: border-box transform: rotateZ(0deg);-webkit-transform: rotateZ(0deg);-moz-transform: rotateZ(0deg);-o-transform: rotateZ(0deg);-webkit-transform: rotateZ(0deg);-moz-transform: rotateZ(0deg);-o-transform: rotateZ(0deg);" opacity="0"><svg xmlns="http://www.w3.org/2000/svg" width="100%" height="100%" style="box-sizing: border-box;" x="0.638998%"><svg width="100%" height="100%" style="box-sizing: border-box;"><rect width="100%" height="100%" style="box-sizing: border-box;opacity: 1;fill: rgb(254, 254, 254);" x="0%"></rect></svg><svg style="width: 100%;height: 100%;box-sizing: border-box;" xmlns="http://www.w3.org/2000/svg"><text x="50%" y="50%" fill="#000000" style="stroke: rgb(0, 0, 0);stroke-width: 1;font-size: 32px;text-anchor: middle;box-sizing: border-box;"> </text></svg><animate attributename="x" style="box-sizing: border-box;" fill="freeze" dur="4" repeatcount="indefinite" begin="0s" keytimes="0;0.5;1" values="-100%;0%;100%"></animate></svg><animate attributename="opacity" style="box-sizing: border-box;" fill="freeze" begin="0s" dur="0.01" from="0" to="1"></animate></svg></section></section></section><section style="margin: 20px 0%;text-align: right;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;vertical-align: bottom;width: 60%;box-sizing: border-box;"><section style="text-align: left;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;box-sizing: border-box;"><section style="margin: 15px 0% 0px;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 100%;vertical-align: top;border-style: none;border-width: 0px;border-radius: 0px;border-color: rgba(95, 156, 239, 0.69);background-color: rgba(191, 225, 238, 0.61);padding: 10px 20px 0px 0px;box-shadow: rgb(191, 225, 238) 0px 0px 0px;box-sizing: border-box;"><section style="margin: -20px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="font-size: 27px;color: rgb(110, 115, 117);line-height: 0.9;letter-spacing: 1.5px;box-sizing: border-box;"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="box-sizing: border-box;">一览众山小</strong></p></section></section></section></section></section></section><section style="text-align: left;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;box-sizing: border-box;"><section style="margin: 15px 0% 0px;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 100%;vertical-align: top;border-style: none;border-width: 0px;border-radius: 0px;border-color: rgb(97, 208, 167);background-color: rgba(191, 225, 238, 0.61);padding: 10px 20px 0px 0px;box-sizing: border-box;"><section style="margin: -20px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="font-size: 27px;color: rgb(110, 115, 117);line-height: 0.9;letter-spacing: 0px;box-sizing: border-box;"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="box-sizing: border-box;">Sustainable</strong></p></section></section></section></section></section></section><section style="text-align: left;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;box-sizing: border-box;"><section style="margin: 15px 0% 0px;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 100%;vertical-align: top;border-style: none;border-width: 0px;border-radius: 0px;border-color: rgb(97, 208, 167);background-color: rgba(191, 225, 238, 0.61);padding: 10px 20px 0px 0px;box-sizing: border-box;"><section style="margin: -20px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="font-size: 27px;color: rgb(110, 115, 117);line-height: 0.9;letter-spacing: 1px;box-sizing: border-box;"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="box-sizing: border-box;">Cities &</strong></p></section></section></section></section><section style="margin: 15px 0% 0px;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 100%;vertical-align: top;border-style: none;border-width: 0px;border-radius: 0px;border-color: rgb(97, 208, 167);background-color: rgba(191, 225, 238, 0.61);padding: 10px 20px 0px 0px;box-sizing: border-box;"><section style="margin: -20px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="font-size: 27px;color: rgb(110, 115, 117);line-height: 0.9;letter-spacing: 1px;box-sizing: border-box;"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="box-sizing: border-box;">Mobility</strong></p></section></section></section></section></section></section><section style="margin: 15px 0% 20px;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 100%;vertical-align: top;border-left: 2px solid rgba(191, 225, 238, 0.61);border-bottom-left-radius: 0px;box-sizing: border-box;"><section style="text-align: justify;font-size: 12px;color: rgb(179, 179, 179);padding: 0px 5px;letter-spacing: 2px;line-height: 1.8;box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="color: rgb(110, 115, 117);box-sizing: border-box;"><strong style="box-sizing: border-box;">城市规划与发展战略</strong></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="color: rgb(182, 182, 182);box-sizing: border-box;">城市综合交通</span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="color: rgb(160, 160, 160);box-sizing: border-box;">公共交通与非机动化出行</span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="color: rgb(160, 160, 160);box-sizing: border-box;">活力街区、街道与城市设计</span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="color: rgb(160, 160, 160);box-sizing: border-box;">量化城市与大数据</span></p></section></section></section><section style="transform: translate3d(-7px, 0px, 0px);-webkit-transform: translate3d(-7px, 0px, 0px);-moz-transform: translate3d(-7px, 0px, 0px);-o-transform: translate3d(-7px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="text-align: left;font-size: 12px;color: rgb(110, 115, 117);line-height: 2;letter-spacing: 0px;padding: 0px 5px;box-sizing: border-box;"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><span style="box-sizing: border-box;"><strong style="box-sizing: border-box;">「」</strong></span><strong style="box-sizing: border-box;"><br style="box-sizing: border-box;"  /></strong></p></section></section><section style="text-align: justify;font-size: 12px;padding: 0px 5px;color: rgb(110, 115, 117);line-height: 1.8;letter-spacing: 2px;box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="box-sizing: border-box;">2020年<span style="box-sizing: border-box;"> | 1</span><span style="box-sizing: border-box;">月26日期</span></strong></p></section></section><section style="display: inline-block;vertical-align: bottom;width: 40%;box-sizing: border-box;"><section style="margin: 0px 0%;font-size: 3px;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 70%;box-shadow: rgb(191, 225, 238) 0px 0px 0px;box-sizing: border-box;"><img data-ratio="0.9324074" data-w="1080" src="http://mmbiz.qpic.cn/mmbiz_png/mee9Bdh9Tia9wPia9GuxWcbb7vh3vsEdCmGARQyiaZtr9svQf8F56HOibWXABFLAaSllTZQXib1sY36ucowFydQR5CA/640?wx_fmt=png" style="vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;" width="100%" data-type="png"  /></section></section></section></section><section style="text-align: center;font-size: 14px;color: rgb(125, 146, 160);line-height: 2;letter-spacing: 5px;padding: 0px 5px;box-sizing: border-box;" powered-by="gulangu"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="font-size: 18px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></strong></p><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="font-size: 18px;box-sizing: border-box;">团队成员</strong><br style="box-sizing: border-box;"  /></p></section><section style="margin: 10px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 100%;vertical-align: top;padding: 15px 10px;background-image: url("http://mmbiz.qpic.cn/mmbiz_png/mHiao3ynqkNvD6fThx0AUTc7W86BzUWV3z72vg3qQsdnH2Yhb4tic93ypOgIO381EibHPPIvicXKot95VxBPMdBZnA/640?wx_fmt=png");background-position: 25.8037% -43.1473%;background-repeat: repeat;background-size: 29.7866%;background-attachment: scroll;box-sizing: border-box;"><section style="box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;vertical-align: top;width: 50%;border-right: 1px dashed rgb(127, 127, 127);border-top-right-radius: 0px;padding: 0px 10px 0px 0px;box-sizing: border-box;"><section style="box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;vertical-align: top;width: 10%;padding: 0px 5px 0px 0px;box-sizing: border-box;"><section style="text-align: center;font-size: 21px;box-sizing: border-box;" powered-by="gulangu"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><em style="box-sizing: border-box;"><span style="text-decoration: underline;box-sizing: border-box;">1</span></em></p></section></section><section style="display: inline-block;vertical-align: top;width: 90%;padding: 0px 0px 0px 5px;border-width: 0px;box-sizing: border-box;"><section style="text-align: center;margin: 0px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><img data-ratio="1" data-w="170" src="http://mmbiz.qpic.cn/mmbiz_jpg/mee9Bdh9Tia9hUqvCTuPLMcEdyzqjq3731NC2CNHhkvrBpafAoVBofcTxia740Vw2jBjF9Cw9CZQwA1diad1J0Aaw/640?wx_fmt=jpeg" style="vertical-align: middle;max-width: 100%;box-sizing: border-box;" data-type="jpeg"  /></section></section></section></section></section><section style="display: inline-block;vertical-align: top;width: 50%;padding: 0px 0px 0px 10px;box-sizing: border-box;"><section style="box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;vertical-align: top;width: 10%;padding: 0px 5px 0px 0px;box-sizing: border-box;"><section style="text-align: center;font-size: 21px;box-sizing: border-box;" powered-by="gulangu"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><em style="box-sizing: border-box;"><span style="text-decoration: underline;box-sizing: border-box;">2</span></em></p></section></section><section style="display: inline-block;vertical-align: top;width: 90%;padding: 0px 0px 0px 5px;border-width: 0px;box-sizing: border-box;"><section style="text-align: center;margin: 0px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><img data-ratio="1" data-w="265" src="http://mmbiz.qpic.cn/mmbiz_jpg/mee9Bdh9Tia9hUqvCTuPLMcEdyzqjq373mWXjl12mYUicMNrXZkHrBib7pQ8uWuiaiarXv63bx6fDGAU2EMIZnpUuyQ/640?wx_fmt=jpeg" style="vertical-align: middle;max-width: 100%;box-sizing: border-box;" data-type="jpeg"  /></section></section></section></section></section></section></section></section><section style="margin: 0px 0% 3px;box-sizing: border-box;" powered-by="gulangu"><section style="text-align: center;font-size: 14px;padding: 0px 20px;line-height: 1.8;letter-spacing: 2px;color: rgb(0, 0, 0);box-sizing: border-box;"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 12px;box-sizing: border-box;"><strong style="box-sizing: border-box;">原文/ </strong></span><span style="font-size: 12px;text-align: justify;box-sizing: border-box;">Peng Zhou、Xing-Lou Yang、Xian-Guang Wang、Ben Hu、Lei Zhang、Wei  Zhang、Hao-Rui Si、Yan Zhu、Bei Li、Chao-Lin Huang、Hui-Dong Chen、Jing   Chen、Yun Luo、Hua Guo、Ren-Di Jiang、Mei-Qin Liu、Ying Chen、Xu Rui Shen、Xi Wang、Xiao-Shuang Zheng、Kai Zhao、Quan-Jiao Chen、Fei  Deng、Lin-Lin Liu、Bing Yan、Fa-Xian Zhan、Yan-Yi Wang、Geng-Fu Xiao、Zheng-Li Shi（石正丽，通讯作者，联系方式：zlshi@wh.iov.cn）以上作者分别来自：中国科学院武汉病毒研究所、中国科学院生物安全大科学中心、中国科学院特殊病原体重点实验室(中国武汉)、中国武汉金银潭医院、中国科学院大学、湖北省疾控中心</span></p><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 12px;box-sizing: border-box;"><strong style="box-sizing: border-box;">翻译/ </strong></span><span style="font-size: 12px;box-sizing: border-box;">相欣奕</span></p><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="font-size: 12px;box-sizing: border-box;">编辑/</strong><strong style="font-size: 12px;box-sizing: border-box;"> </strong><span style="font-size: 12px;box-sizing: border-box;">众山小</span><strong style="font-size: 12px;box-sizing: border-box;">   校核/ </strong><span style="font-size: 12px;box-sizing: border-box;">众山小</span><br style="box-sizing: border-box;"  /></p><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 12px;box-sizing: border-box;"><strong style="box-sizing: border-box;">文献/ </strong></span><span style="font-size: 12px;box-sizing: border-box;">许涵泳</span><strong style="font-size: 12px;box-sizing: border-box;">   排版/ </strong><span style="font-size: 12px;box-sizing: border-box;">蒋睿婕</span></p><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><span style="box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="font-size: 12px;box-sizing: border-box;">微博 |</span></strong><span style="font-size: 12px;box-sizing: border-box;"> weibo.com/</span></span></p></section></section><section style="text-align: center;margin: 0px 0%;transform: translate3d(15px, 0px, 0px);-webkit-transform: translate3d(15px, 0px, 0px);-moz-transform: translate3d(15px, 0px, 0px);-o-transform: translate3d(15px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 12%;box-sizing: border-box;"><img data-ratio="1" data-w="120" src="http://mmbiz.qpic.cn/mmbiz_png/mee9Bdh9Tia9wPia9GuxWcbb7vh3vsEdCmaUJt64sSficUZ9P4qYPKoyPI7hD8RxNBv438UR18bcficGmbf7ABCpFA/640?wx_fmt=png" style="vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;" width="100%" data-type="png"  /></section></section><section style="text-align: center;margin: 10px 0% 20px;transform: translate3d(-50px, 0px, 0px);-webkit-transform: translate3d(-50px, 0px, 0px);-moz-transform: translate3d(-50px, 0px, 0px);-o-transform: translate3d(-50px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 8%;height: auto;box-sizing: border-box;"><img data-ratio="1" data-w="120" src="http://mmbiz.qpic.cn/mmbiz_png/mee9Bdh9Tia9wPia9GuxWcbb7vh3vsEdCmaUJt64sSficUZ9P4qYPKoyPI7hD8RxNBv438UR18bcficGmbf7ABCpFA/640?wx_fmt=png" style="vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;" width="100%" data-type="png"  /></section></section><section style="text-align: center;margin: -55px 0% 10px;transform: translate3d(1px, 0px, 0px);-webkit-transform: translate3d(1px, 0px, 0px);-moz-transform: translate3d(1px, 0px, 0px);-o-transform: translate3d(1px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 15%;height: auto;box-sizing: border-box;"><img data-ratio="1" data-w="120" src="http://mmbiz.qpic.cn/mmbiz_png/mee9Bdh9Tia9wPia9GuxWcbb7vh3vsEdCm1y6VEsIU2KMraBP7ybrKwptiaBVLaXBAz66wIRzxazicjSCDTFjq4fGg/640?wx_fmt=png" style="vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;" width="100%" data-type="png"  /></section></section><section style="margin: 0px 0%;text-align: center;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 100%;border-color: rgb(239, 70, 70);border-style: none;border-width: 1px;background-color: rgb(182, 182, 182);border-radius: 0px;box-sizing: border-box;"><section style="margin: -18px 0% 10px;font-size: 8px;box-sizing: border-box;" powered-by="gulangu"><section style="background-color: rgb(255, 255, 255);display: inline-block;width: 2.5em;height: 2.5em;line-height: 2.5em;border-radius: 100%;margin-left: auto;margin-right: auto;font-size: 14px;color: rgb(255, 255, 240);box-sizing: border-box;"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section></section><section style="text-align: right;transform: translate3d(-40px, 0px, 0px);-webkit-transform: translate3d(-40px, 0px, 0px);-moz-transform: translate3d(-40px, 0px, 0px);-o-transform: translate3d(-40px, 0px, 0px);margin: 0px 0% 10px;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 20%;vertical-align: top;border-style: solid;border-width: 3px;border-radius: 0px;border-color: rgb(255, 255, 255);box-sizing: border-box;"><section style="margin: 10px 0%;transform: translate3d(5px, 0px, 0px);-webkit-transform: translate3d(5px, 0px, 0px);-moz-transform: translate3d(5px, 0px, 0px);-o-transform: translate3d(5px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="text-align: center;font-size: 22px;color: rgb(246, 246, 246);line-height: 1.8;letter-spacing: 5px;padding: 0px;box-sizing: border-box;"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-family:Optima-Regular, PingFangTC-light;box-sizing: border-box;"><strong style="box-sizing: border-box;">一览导读</strong></span></p></section></section></section></section><section style="margin: 10px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 96%;vertical-align: top;box-shadow: rgb(55, 120, 153) 0px 0px 6px;border-width: 0px;border-style: none;border-color: rgb(239, 70, 70);border-radius: 8px;overflow: hidden;box-sizing: border-box;"><section style="text-align: right;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 100%;vertical-align: top;padding: 10px 15px 8px;box-shadow: rgb(239, 175, 17) 0px 0px 0px;box-sizing: border-box;"><section style="margin: 10px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="text-align: justify;font-size: 14px;color: rgb(255, 255, 255);padding: 0px 10px;line-height: 1.8;letter-spacing: 2px;box-sizing: border-box;"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;">自18年前SARS暴发以来，研究者在天然宿主——蝙蝠体内发现了大量与严重呼吸道症候相关的冠状病毒（SARSr-CoV）。前期研究表明，上述某些冠状病毒可能会导致人类感染。本文对当前中国武汉正在流行的肺炎病毒（nCoV-2019）加以识别与表征。此次疫情起于2019年12月12日，至2020年1月20日已实验室确诊198例，致死3例。<span style="text-decoration: underline;color: rgb(110, 65, 157);box-sizing: border-box;"><strong style="box-sizing: border-box;">从疫情暴发早期的5名患者身上提取了全长度基因组序列。它们彼此几乎相同，并且与SARS-CoV的基因序列有79.5％相同。</strong></span>此外，研究发现<span style="text-decoration: underline;color: rgb(110, 65, 157);box-sizing: border-box;"><strong style="box-sizing: border-box;">在整个基因组水平上，nCoV-2019与蝙蝠冠状病毒的同源性达96％。</strong></span>针对7个保守非结构蛋白质开展成对蛋白序列分析表明，该<span style="text-decoration: underline;color: rgb(110, 65, 157);box-sizing: border-box;"><strong style="box-sizing: border-box;">病毒属于SARSr-CoV种。</strong></span>从重症患者的支气管肺泡灌洗液中分离出nCoV-2019病毒，数名<span style="text-decoration: underline;color: rgb(110, 65, 157);box-sizing: border-box;"><strong style="box-sizing: border-box;">患者的血清对于分离出的病毒产生中和作用。</strong></span>我们的另一个重要发现在于，确认<span style="text-decoration: underline;color: rgb(110, 65, 157);box-sizing: border-box;"><strong style="box-sizing: border-box;">这一新型CoV与SARS-CoV采用相同的细胞进入受体——ACE2。</strong></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="text-decoration: underline;box-sizing: border-box;"><strong style="box-sizing: border-box;"><br style="box-sizing: border-box;"  /></strong></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><em style="box-sizing: border-box;">注：本文于2020年1月23日由bioRxiv在线预出版发布，版权归作者和资助方所有，鉴于疫情紧急，“一览众山小”公号未经获得版权人授权，在线下载获取之后由志愿者翻译并共享，以期供相关人员参考，为抵抗新冠疫情尽绵薄之力。版权人如有任何反对意见，请联系本号撤销。限于译者只有环境化学背景，并无病毒学专业背景，译文或有疏漏之处，欢迎留言指正。</em></p><p style="text-align: left;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 10px;box-sizing: border-box;"><em style="box-sizing: border-box;">（Granted bioRxiv a license to display the preprint in The copy right holder for. </em><span style="text-decoration: underline;box-sizing: border-box;"><em style="box-sizing: border-box;"><span style="text-decoration: underline;box-sizing: border-box;">http://dx.doi.org/10.1101/2020.01.22.914952. doi: bioRxiv preprint first posted online Jan.23,2020;</span></em></span><em style="box-sizing: border-box;"> ）</em></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section></section></section></section></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section></section></section><section style="text-align: left;margin: -70px 0% 0px;font-size: 18px;transform: translate3d(-10px, 0px, 0px);-webkit-transform: translate3d(-10px, 0px, 0px);-moz-transform: translate3d(-10px, 0px, 0px);-o-transform: translate3d(-10px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="width: 5em;height: 5em;margin: auto;display: inline-block;vertical-align: bottom;text-align: center;border-radius: 100%;background-color: rgb(255, 255, 255);box-sizing: border-box;"><section style="display: table;width: 100%;height: 5em;box-sizing: border-box;"><section style="display: table-cell;vertical-align: middle;width: 100%;line-height: 1.2;color: rgb(125, 146, 160);font-size: 15px;padding: 10px;letter-spacing: 2px;box-sizing: border-box;"><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="box-sizing: border-box;">阅读</strong></p><p style="margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="box-sizing: border-box;">正文</strong></p></section></section></section></section><section style="text-align: left;margin: 0px 0%;transform: translate3d(30px, 0px, 0px);-webkit-transform: translate3d(30px, 0px, 0px);-moz-transform: translate3d(30px, 0px, 0px);-o-transform: translate3d(30px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 35%;vertical-align: top;box-sizing: border-box;"><section style="margin: 10px 0% 20px;box-sizing: border-box;" powered-by="gulangu"><section style="background-color: rgba(160, 160, 160, 0.62);height: 3px;box-sizing: border-box;line-height: 0;"><br  /></section></section></section></section><section style="margin: 5px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="font-size: 14px;color: rgb(79, 79, 79);line-height: 1.8;letter-spacing: 2px;padding: 0px 10px;box-sizing: border-box;"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;">20年来，冠状病毒已引发两次大规模疫病流行，SARS（非典）和MERS（中东呼吸综合征）。人们也普遍认为，SARSr-CoV（主要存在于蝙蝠体内）可能会导致下一波疾病暴发。中国湖北武汉市近期暴发了（译者注：文章提交时）未确定的肺炎疫情，起自当地海鲜市场，至2020年1月20日已实验室确诊198例，致死3例。病患者典型症候为发热、干咳、呼吸困难、头痛和肺炎。随着病情进展，因肺泡损伤会导致呼吸衰竭乃至死亡。临床症状和实验室检测表现如下：临床体温升高，淋巴细胞和白细胞减少（有时为正常），胸片上出现新的肺浸润。如若经抗生素治疗三天无明显好转，即可诊断为病毒性肺炎。似乎大多数早期病例都有与海鲜市场的接触史，目前为止（译者注：文章提交时），尚未观察到大规模的人际传播。</p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;">在肺炎开始暴发时，从重症监护的7名患者（其中有6名是海鲜市场商贩或送货工）中提取的样本被送至WIV实验室开展病原体诊断（参见扩展数据表1）。作为一个冠状病毒实验室，考虑到这次疫病与SARS同样暴发于冬季且发生在相同的市场环境之中，我们首先使用pan-CoV PCR引物对这些样品开展测试。测试发现5个PCR结果呈阳性。使用二代测序（NGS）通过宏基因组分析针对从支气管肺泡灌洗液（BALF）收集的样品（WIV04）进行分析，以鉴定潜在的病原体。在把人类基因组滤过之后获得的1582个读数中，有1378个（87.1％）与SARSr-CoV序列匹配（图1a）。经由基因组从头测序和靶向PCR，我们得到了一个与SARS-CoV BJ01（GenBank登录号AY278488.2）共享79.5％序列的29,891-bp CoV基因组。我们已把该序列提交给GISAID（登录号为69 EPI_ISL_402124）。按照WHO命名规则，我们将其暂定名为新型冠状病毒2019（nCoV-2019）。随后又从另外四名患者体中获得了四个nCoV-2019（WIV02，WIV05，WIV06和WIV07）的全长基因组序列（GISAID登录号EPI_ISL_402127-402130），彼此之间的同源性高于99.9％（参见扩展数据表2）。病毒基因组由冠状病毒共有的六种主要开放阅读框（ORF）和若干其他辅助基因组成（图1b）。进一步的分析表明，某些nCoV-2019基因与SARS-CoV共享的核苷酸序列同源性低于80％。然而，用于CoV物种分类的ORF1ab中的7个保守复制酶结构域，nCoV-2019和SARS-CoV具有94.6％的氨基酸序列同源性，这意味着两者属于同一病毒种（扩展数据表3）。</p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section></section><section style="text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><img src="http://mmbiz.qpic.cn/mmbiz_png/mee9Bdh9Tia9hUqvCTuPLMcEdyzqjq3734RvxRqHCU7HUZyQmuewztS6LRefJpVEePztL0iabic8Kicw1lffPHCibibw/640?wx_fmt=png" style="vertical-align: middle;max-width: 100%;box-sizing: border-box;" data-type="png" data-ratio="0.6046296296296296" data-w="1080"  /></section></section><section style="box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">图一、</strong></em><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">nCoV-2019的基因组表征</strong></em></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">a，饼图显示了来自患者ICU06的支气管肺泡灌洗液二代测序的宏基因组学分析。</strong></em></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">b，nCoV-2019 WIV04的基因组结构。</strong></em></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">c，基于nCoV-2019 WIV04的全长基因组序列的同源性图示。</strong></em></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">d，基于冠状病毒完整ORF1b核苷酸序列的系统树（可以在全文“材料和方法”部分找到所使用的软件和设置）。</strong></em></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section><section style="margin: 5px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="font-size: 14px;color: rgb(79, 79, 79);line-height: 1.8;letter-spacing: 2px;padding: 0px 10px;box-sizing: border-box;"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;">我们从蝙蝠冠状病毒中发现了一个短的RdRp区域，名为蝙蝠冠状病毒RaTG13，这是我们先前在云南省菊头蝠（Rhinolophus affinis）体内检测到的片段，与nCoV-2019具有高度序列同源性。我们对该RNA样品进行了全长测序。Simplot分析显示，nCoV-2019在全基因组中与RaTG1 3高度相似（图1c），整体基因组序列一致性为96.2％。系统发生分析显示，RaTG13是nCoV-2019的最近亲，与其他SARSr-CoV形成明显的世系（图1d）。受体结合蛋白刺突（S）基因与其他CoVs存在显著不同（扩展数据图2），与所有先前描述的SARSr-CoVs的核苷酸序列同源性均低于75％，但与RaTG13却具有93.1％的核苷酸同源性（扩展数据表3）。nCoV-2019和RaTG13 S的S基因比其他SARSr-CoVs的S基因长。与SARS-CoV相比，nCoV-2019的主要区别在于N末端结构域中的三个短插入和五个受体残基中的四个关键残基发生了变化（扩展数据表3）。nCoV-2019与RaTG13之间密切的系统发育关系，为nCoV-2019源自于蝙蝠提供了证据。</p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;">我们基于穗状突基因的受体结合结构域快速开发了一种qPCR检测方法，穗状突基因是基因组中变化最大的区域（图1c）。我们的数据显示，这些引物可以将nCoV-2019与所有其他人类冠状病毒（包括蝙蝠SARSr-CoV WIV1）区分开，它与SARS-CoV具有95％的同源性（扩展数据表4a和4b）。就上述7例患者而言，我们在通过qPCR和常规PCR开展的首次采样，在6个BALF（译者注：支气管肺泡灌洗液）和5个口腔拭子样本中发现nCoV-2019阳性（扩展数据图4c）。但是，在第二次采样期间，我们再也无法在这些患者的口腔拭子，肛门拭子和血液中发现病毒阳性（图2a）。基于上述发现，我们得出结论是，该疾病应该是通过呼吸道传播，但如果调查范围扩大到包括更多患者，不能排除其他可能性。</p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;">对于nCoV-2019的血清学检测，我们使用了先前开发的蝙蝠SARSr-CoV Rp3核衣壳蛋白（NP）作为IgG和IgM ELISA测试中的抗原，该抗体与SARSr-CoV7以外的其他人类冠状病毒没有交叉反应性。作为研究实验室，我们只能从7名病毒感染患者中获得5个血清样本。我们针对一名患者（ICU-06）发病第7、8、9和18天的病毒抗体水平加以监测（扩展数据表2）。观察到IgG和IgM滴度明显增加的趋势（在最后一天转为下降）（图2b）。我们的第二项研究是，在发病后20天左右对7名病毒阳性患者中的5名进行病毒抗体检测（扩展数据表1和2）。与健康人的样本不同，所有患者样本都显示出很强的病毒IgG阳性（图2b）。我们还发现了三个IgM阳性，表明是急性感染。</p></section></section><section style="text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><img src="http://mmbiz.qpic.cn/mmbiz_jpg/mee9Bdh9Tia9hUqvCTuPLMcEdyzqjq373A1z2IZBszMsCW52GcFNyZWMhVHe69CFYXzBPEKCIqSOnJ5pt0CeWvw/640?wx_fmt=jpeg" style="vertical-align: middle;max-width: 100%;box-sizing: border-box;" data-type="jpeg" data-ratio="0.75" data-w="1080"  /></section></section><section style="font-size: 14px;box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="box-sizing: border-box;"><em style="box-sizing: border-box;">图二、患者样本的分子和血清学研究</em></strong></p></section><section style="letter-spacing: 2px;padding: 0px 10px;line-height: 1.8;box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;">随后，我们使用ICU-06患者的BALF样本成功在Vero和Huh7细胞中成功分离出了该病毒（名为nCoV-2019 BetaCoV / Wuhan / WIV04 / 2019）。孵育三天后，在细胞中观察到了明显的致细胞病变作用（扩展数据图5a和5b）。通过使用交叉反应性病毒NP抗体的免疫荧光显微镜检查（图5c和5d）以及经由宏基因组测序，在Vero E6细胞中验证了WIV04菌株的身份，大部分读数都映射到nCoV-2019（扩展表5e和5f）。在电子显微镜下，感染细胞的超薄切片中的病毒部分显示出典型的冠状病毒形态（图3）。为了进一步确认病毒IgG阳性样品的中和活性，我们使用五份IgG阳性患者血清在Vero E6细胞中进行了血清中和测定，结果证明所有样品均能够以1：40-1：80的稀释度中和TCID50 nCoV-2019。我们还发现，该病毒可以被1:80稀释度的马的抗SARS-CoV血清交叉中和，进一步证实了这两种病毒之间的关系（扩展数据表4）。</span></p></section><section style="text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><img src="http://mmbiz.qpic.cn/mmbiz_png/mee9Bdh9Tia9hUqvCTuPLMcEdyzqjq373QD5lHBbdIOffMmyHZwoGEmmtt5tUZphLhd19ompOFtBB53jbgqzKdA/640?wx_fmt=png" style="vertical-align: middle;max-width: 100%;box-sizing: border-box;" data-type="png" data-ratio="0.9607623318385651" data-w="892"  /></section></section><section style="box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;">图三、电子显微镜下的病毒粒子</span></strong></em></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></span></strong></em></p></section><section style="margin: 5px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="font-size: 14px;color: rgb(79, 79, 79);line-height: 1.8;letter-spacing: 2px;padding: 0px 10px;box-sizing: border-box;"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;">已知血管紧张素转化酶II（ACE2）被视为SARS-CoV14的细胞受体。为了确定nCoV-2019是否也使用ACE2作为细胞进入受体，我们使用表达或不表达ACE2蛋白的人类、马蹄蝠、麝猫、猪和小鼠的HeLa细胞进行了病毒感染性研究。我们发现nCoV-2019能够使用除小鼠ACE2以外的所有基因作为该基因的进入受体。而缺失ACE2的细胞则不能被感染。证明其可能是nCoV-2019的细胞受体（图4）。我们还证明了nCoV-2019并不使用其他冠状病毒受体、氨肽酶N和二肽基肽酶4（扩展数据表6）。</p></section></section><section style="text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><img src="http://mmbiz.qpic.cn/mmbiz_jpg/mee9Bdh9Tia9hUqvCTuPLMcEdyzqjq373YOXD0YwYBXO5WT9dr6v7Pml4iaCY4RRdSNXhoYVv7rNvhccHXFGuRZw/640?wx_fmt=jpeg" style="vertical-align: middle;max-width: 100%;box-sizing: border-box;" data-type="jpeg" data-ratio="1.1754874651810585" data-w="718"  /></section></section><section style="box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;">图四、nCoV-2019受体使用情况分析 </strong></em></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"><em style="box-sizing: border-box;"><strong style="box-sizing: border-box;"><br style="box-sizing: border-box;"  /></strong></em></span></p></section><section style="line-height: 1.8;letter-spacing: 2px;padding: 0px 10px;box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;">该研究提供了关于nCoV-2019的第一份详细报告，</span><span style="font-size: 14px;text-decoration: underline;box-sizing: border-box;"><strong style="box-sizing: border-box;">nCoV-2019是造成中国中部武汉市持续性急性呼吸道综合症流行的成因。</strong></span><span style="font-size: 14px;box-sizing: border-box;">在所有测试的患者中观察到的病毒特异性核苷酸阳性和病毒蛋白血清转化提供了该疾病与该病毒的存在之间的关联的证据。但是，仍然有许多迫切问题需要解决。我们需要更多的临床数据和样本来确认这种病毒是否确实是该流行病的病原体。此外，我们仍然不知道这种病毒是否会继续发展并在人与人之间传播。我们也尚不知晓该病毒在宿主之间的传播途径。</span><span style="font-size: 14px;text-decoration: underline;box-sizing: border-box;"><strong style="box-sizing: border-box;">我们在口腔拭子中发现了病毒阳性测试结果，这意味着nCoV-2019可能通过气道传播。</strong></span><span style="font-size: 14px;box-sizing: border-box;">但是，这需要通过扩大检测范围来确认。最后，基于我们的结果，</span><span style="font-size: 14px;text-decoration: underline;box-sizing: border-box;"><strong style="box-sizing: border-box;">可以预期并且值得测试ACE2靶向药物或SARS-CoV靶向药物可否适用于nCoV-2019患者。</strong></span><span style="font-size: 14px;box-sizing: border-box;">在此阶段，我们对该病毒知之甚少，包括基本生物学、动物来源或任何特定治疗方法。该病毒在不同患者中几乎相同的序列暗示着其可能是最近进入人类中的，因此</span><span style="font-size: 14px;text-decoration: underline;box-sizing: border-box;"><strong style="box-sizing: border-box;">迫切需要对病毒突变和传播能力的未来监测以及进一步的全球研究投以关注。</strong></span></p></section><section style="text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><img data-ratio="0.562963" data-w="1080" src="http://mmbiz.qpic.cn/mmbiz_jpg/mee9Bdh9Tia9hUqvCTuPLMcEdyzqjq373hnPttzHL1grtxKyMTMbn47D20zjRRdHw8kqTzJ8yMEdyicPYhTEzOlQ/640?wx_fmt=jpeg" style="vertical-align: middle;max-width: 100%;box-sizing: border-box;" data-type="jpeg"  /></section></section><section style="box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section><section style="opacity: 0.2;transform: translate3d(79px, 0px, 0px);-webkit-transform: translate3d(79px, 0px, 0px);-moz-transform: translate3d(79px, 0px, 0px);-o-transform: translate3d(79px, 0px, 0px);margin: 0px 0% -13px;box-sizing: border-box;" powered-by="gulangu"><section style="font-size: 18px;color: rgb(160, 160, 160);letter-spacing: 6px;font-family: PingFangSC-light;box-sizing: border-box;"><p style="text-indent: 0em;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;">致谢</p></section></section><section style="transform: translate3d(10px, 0px, 0px);-webkit-transform: translate3d(10px, 0px, 0px);-moz-transform: translate3d(10px, 0px, 0px);-o-transform: translate3d(10px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;vertical-align: top;width: 20%;height: 1px;box-sizing: border-box;line-height: 0;"><br  /></section><section style="display: inline-block;vertical-align: top;width: 60%;height: auto;box-sizing: border-box;"><section style="font-size: 32px;color: rgba(38, 176, 231, 0.79);letter-spacing: 3px;box-sizing: border-box;" powered-by="gulangu"><p style="text-indent: 0em;white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><strong style="box-sizing: border-box;">致谢</strong></p></section></section></section><section style="letter-spacing: 2px;padding: 0px 10px;line-height: 1.8;box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;">对来自WIV核心机构的Pei Zhang和An-na Du致谢，感谢他们提供的技术支持以及制作的TEM显微照片。</span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"> </span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;">本研究得到中国科学院战略重点研究计划（(XDB29010101 to ZLS 及 XDB29010104 to PZ)以及中国自然科学基金重点项目（PZ 81822028，ZLS 31770175，BH 31800142），中华人民共和国科学技术部传染病重大项目（DYZ 2020ZX09201001和DYZ 2018ZX10305409-004-001），中国科学院青年创新促进会项目（XLY 2019328）的共同支持。</span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;"> </span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="color: rgba(38, 176, 231, 0.79);box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="font-size: 14px;box-sizing: border-box;">一览众山小为您提供本文英文原文。</span></strong></span></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section><section style="text-align: left;margin: 0px 0%;transform: translate3d(30px, 0px, 0px);-webkit-transform: translate3d(30px, 0px, 0px);-moz-transform: translate3d(30px, 0px, 0px);-o-transform: translate3d(30px, 0px, 0px);box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 35%;vertical-align: top;box-sizing: border-box;"><section style="margin: 10px 0% 20px;box-sizing: border-box;" powered-by="gulangu"><section style="background-color: rgba(160, 160, 160, 0.62);height: 3px;box-sizing: border-box;line-height: 0;"><br  /></section></section></section></section><section style="text-align: center;margin: 0px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><img src="http://mmbiz.qpic.cn/mmbiz_png/mee9Bdh9Tia9wPia9GuxWcbb7vh3vsEdCmHoMxDAfdOPOsJAYoEKWPstJC8iasgCxRoYqStN5V2ygzkromHf5EKfw/640?wx_fmt=png" style="vertical-align: middle;max-width: 100%;box-sizing: border-box;" data-type="png" data-ratio="0.26426426426426425" data-w="666"  /></section></section><section style="box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section><section style="text-align: right;margin: -5px 0% 0px;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 50%;height: 30px;vertical-align: top;overflow-y: auto;box-sizing: border-box;-webkit-overflow-scrolling: touch;"><section style="overflow-x: hidden;box-sizing: border-box;"><section style="margin: 22px 0% 0px;box-sizing: border-box;" powered-by="gulangu"><section style="background-color: rgba(160, 160, 160, 0.62);height: 4px;box-sizing: border-box;line-height: 0;"><br  /></section></section><section style="margin: 0px 0%;box-sizing: border-box;" powered-by="gulangu"><section style="background-color: rgba(160, 160, 160, 0.62);height: 4px;box-sizing: border-box;line-height: 0;"><br  /></section></section></section></section><section style="box-sizing: border-box;margin-top: -30px;height: 30px;"><section style="height: 100%;box-sizing: border-box;"><svg width="50%" height="100%" xmlns="http://www.w3.org/2000/svg" style="box-sizing: border-box transform: rotateZ(0deg);-webkit-transform: rotateZ(0deg);-moz-transform: rotateZ(0deg);-o-transform: rotateZ(0deg);-webkit-transform: rotateZ(0deg);-moz-transform: rotateZ(0deg);-o-transform: rotateZ(0deg);" opacity="0"><svg xmlns="http://www.w3.org/2000/svg" width="100%" height="100%" style="box-sizing: border-box;" x="0.638998%"><svg width="100%" height="100%" style="box-sizing: border-box;"><rect width="100%" height="100%" style="box-sizing: border-box;opacity: 1;fill: rgb(254, 254, 254);" x="0%"></rect></svg><svg style="width: 100%;height: 100%;box-sizing: border-box;" xmlns="http://www.w3.org/2000/svg"><text x="50%" y="50%" fill="#000000" style="stroke: rgb(0, 0, 0);stroke-width: 1;font-size: 32px;text-anchor: middle;box-sizing: border-box;"> </text></svg><animate attributename="x" style="box-sizing: border-box;" fill="freeze" dur="4" repeatcount="indefinite" begin="0s" keytimes="0;0.5;1" values="-100%;0%;100%"></animate></svg><animate attributename="opacity" style="box-sizing: border-box;" fill="freeze" begin="0s" dur="0.01" from="0" to="1"></animate></svg></section></section></section><section style="margin: 10px 0% 0px;box-sizing: border-box;" powered-by="gulangu"><section style="text-align: right;font-size: 14px;color: rgb(255, 255, 255);line-height: 2;letter-spacing: 2.5px;padding: 0px 20px;font-family: PingFangSC-light;box-sizing: border-box;"><p style="text-indent: 2em;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="background-color: rgb(149, 218, 243);box-sizing: border-box;"><strong style="box-sizing: border-box;">同鼠疫做斗争，唯一的方式就是诚挚。<span style="text-indent: 2em;box-sizing: border-box;">我不知道诚挚通常指什么。但是就我的情况而言，我知道诚挚就是做好本职工作。</span></strong></span></p><p style="text-indent: 2em;margin: 0px;padding: 0px;box-sizing: border-box;"><span style="background-color: rgb(149, 218, 243);box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="text-indent: 2em;box-sizing: border-box;">——加缪</span></strong></span></p></section></section><section style="text-align: right;box-sizing: border-box;" powered-by="gulangu"><section style="text-align: justify;box-sizing: border-box;"><p style="margin: 0px;white-space: normal;padding: 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normal;margin: 0px;padding: 0px;box-sizing: border-box;">微信公众号 后台留言<br style="box-sizing: border-box;"  /></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;">或电邮 Daizongliu@qq.com </p></section></section><section style="margin: 10px 0%;text-align: center;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 100%;border-color: rgb(181, 190, 143);border-style: none;border-width: 1px;background-color: rgb(125, 146, 160);border-radius: 0px;box-sizing: border-box;"><section style="text-align: justify;box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section><section style="margin-top: 10px;margin-bottom: 10px;font-size: 18px;box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;border-radius: 6px;line-height: 1.6em;background-color: rgb(255, 255, 255);box-sizing: 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/></p></section></section></section><section style="box-sizing: border-box;" powered-by="gulangu"><section style="display: inline-block;width: 80%;vertical-align: top;box-sizing: border-box;"><section style="font-size: 12px;color: rgb(160, 160, 160);line-height: 2;letter-spacing: 2px;padding: 0px 10px;box-sizing: border-box;" powered-by="gulangu"><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;">我们作为独立的专业志愿者团体，秉承专业理想与价值观，不依托任何机构，信守非盈利原则，帮助中国城市可持续发展。我们关注的领域包括但不限于：城市规划与发展战略、城市交通、公共交通与非机动化出行、活力街区、街道与城市设计、量化城市与大数据。至今我们已经拥有遍布全球近430名志愿者网络，并推送2000篇专业微文。作为微信公众号平台最大的线上专业志愿者团体，我们感谢您对我们的关注和支持，并欢迎加入我们！</p><p style="white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;"><br style="box-sizing: border-box;"  /></p></section></section></section><section style="box-sizing: border-box;" powered-by="gulangu"><p style="text-align: 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